Evaluation of Live Attenuated Influenza Vaccines in Children 6–18 Months of Age: Safety, Immunogenicity, and Efficacy
Identifieur interne : 001C28 ( Main/Exploration ); précédent : 001C27; suivant : 001C29Evaluation of Live Attenuated Influenza Vaccines in Children 6–18 Months of Age: Safety, Immunogenicity, and Efficacy
Auteurs : William C. Gruber [États-Unis] ; Robert B. Belshe [États-Unis] ; James C. King [États-Unis] ; John J. Treanor [États-Unis] ; P. A. Piedra [États-Unis] ; Peter F. Wright [États-Unis] ; George W. Reed [États-Unis] ; Edwin Anderson [États-Unis] ; Fran Newman [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1996.
Abstract
Live attenuated, cold-adapted (ca) monovalent and bivalent influenza A vaccines were evaluated in seronegative infants (ages 6–18 months) in a double-blind placebo-controlled trial to assess safety and immunogenicity. A total of 182 seronegative subjects received a single intranasal dose (106.2 TCID50) of ca A/Kawasaki/9/86 (H1N1) or ca A/LosAngeles/2/87 (H3N2), both as a bivalent vaccine, or placebo. Respiratory and systemic symptoms did not differ between groups after vaccination. Hemagglutination antibody seroconversions (⩾1:8)to H3N2 exceeded 90%. In contrast, seroconversions to A/Kawasaki/9/86 (HINl) were significantly less frequent in bivalent ca vaccine recipients (31%) than in monovalent ca H1N1 recipients (83%) (P < .002). During a subsequent H3N2 epidemic, nasal washes were cultured for viruses from any subject with respiratory illness. H3N2 infections documented by virus isolation were reduced by 65% in ca H3N2 recipients compared with placebo or ca H1N1 recipients (P = .01).
Url:
DOI: 10.1093/infdis/173.6.1313
Affiliations:
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Treanor</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Piedra, P A" sort="Piedra, P A" uniqKey="Piedra P" first="P. A." last="Piedra">P. A. Piedra</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. 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A total of 182 seronegative subjects received a single intranasal dose (106.2 TCID50) of ca A/Kawasaki/9/86 (H1N1) or ca A/LosAngeles/2/87 (H3N2), both as a bivalent vaccine, or placebo. Respiratory and systemic symptoms did not differ between groups after vaccination. Hemagglutination antibody seroconversions (⩾1:8)to H3N2 exceeded 90%. In contrast, seroconversions to A/Kawasaki/9/86 (HINl) were significantly less frequent in bivalent ca vaccine recipients (31%) than in monovalent ca H1N1 recipients (83%) (P < .002). During a subsequent H3N2 epidemic, nasal washes were cultured for viruses from any subject with respiratory illness. H3N2 infections documented by virus isolation were reduced by 65% in ca H3N2 recipients compared with placebo or ca H1N1 recipients (P = .01).</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Gruber, William C" sort="Gruber, William C" uniqKey="Gruber W" first="William C." last="Gruber">William C. Gruber</name></region><name sortKey="Anderson, Edwin" sort="Anderson, Edwin" uniqKey="Anderson E" first="Edwin" last="Anderson">Edwin Anderson</name><name sortKey="Belshe, Robert B" sort="Belshe, Robert B" uniqKey="Belshe R" first="Robert B." last="Belshe">Robert B. Belshe</name><name sortKey="Gruber, William C" sort="Gruber, William C" uniqKey="Gruber W" first="William C." last="Gruber">William C. Gruber</name><name sortKey="King, James C" sort="King, James C" uniqKey="King J" first="James C." last="King">James C. King</name><name sortKey="Newman, Fran" sort="Newman, Fran" uniqKey="Newman F" first="Fran" last="Newman">Fran Newman</name><name sortKey="Piedra, P A" sort="Piedra, P A" uniqKey="Piedra P" first="P. A." last="Piedra">P. A. Piedra</name><name sortKey="Reed, George W" sort="Reed, George W" uniqKey="Reed G" first="George W." last="Reed">George W. Reed</name><name sortKey="Treanor, John J" sort="Treanor, John J" uniqKey="Treanor J" first="John J." last="Treanor">John J. Treanor</name><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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